Plasma and Erythrocyte Enzymes in Phenylhydrazine Anemia

Plasma and erythrocyte enzymes in phenylhydrazine anemia.

SEVERAL YEARS AGO LaDue (2) made the iiiteresting observation that soon after myocardial infarction the plasma glutamic oxalacetie tramisammase is increased, reaches a peak within a few days, and then returns to normal. This observation stimulated a new area of clinical interest ill diseases related to infarction and necrosis as manifested ill plasma enzymes changes. The source of this increase...

Cardiac hypertrophy in rats with phenylhydrazine anemia.

THIS investigation was undertaken for the purpose of studying the effect of anemia upon the hearts of rats, of determining whether cardiac hypertrophy occurs, and, if so, of studying the mechanism of hypertrophy. In spite of the widespread belief that cardiac hypertrophy does occur with anemia, Stembridge and Rigdon have indicated the lack of evidence to support many of the reported cases. Thei...

Erythrocyte and Plasma Lipids in Sickle Cell Anemia.

Dehydrogenase of regenerating red blood cells in phenylhydrazine anemia.

Dehydrogenase activities in red blood cells of rabbits made anemic with phenyihydrazinc were assayed. These assays were continued at the time of reticulocytosis and followed through the course of in vivo maturation of the reticulocytes to a younger erythrocyte population. Isocitric, glucose-6-phosphate, and 6-phosphogluconic dehydrogenases were more active in the reticulocytes. Isocitric and gl...

Erythrocyte creatine levels in anemia.

The automated diacetyl-l-napthol procedure was found to be a simple and relatively quick method for the determination of erythrocyte creatine (EC), exhibiting both better precision and greater sensitivity than reticulocyte counting. A reference range of 1.8 to 5.0 mg per dl (mean, 3.0 +/- 0.9 mg per dl) was established by measuring EC levels in 81 normal adults varying in ages from 20 to 47 yea...